Is Autism The Consequence Of Genetic Dysfunctions? ? ArticleLearn.net

Autism is a complex neurological dysfunction that involves abnormalities on the stage of the central nervous system. Although the specific causes of autism in remain unknown, evidently acquired or inherited genetic dysfunctions have a very important role within the occurrence of the syndrome in people. Current experiments carried out on mice have proved that there?s a clear connection between genetic components and irregular behaviors characteristic to ASD (autism spectrum issues). By deleting the PTEN gene in some areas of the mind of mice, scientists have been in a position to set off signs which are similar to those generated by autism in humans.

Although the experiment cannot clarify the precise phenomenon that leads to the development of autism in individuals, the results recommend that autistic people current abnormalities in a region of the mind known as hippocampus. When researchers deleted the PTEN gene within the hippocampus of mice, the results were remarkable. The mice with the PTEN gene deleted shortly began to observe the behavioral patterns generated by autism in humans. The irregular mice confirmed clear indicators of impairment at the levels of social interactions, quickly losing their interest in different mice. The mice with the PTEN gene deleted suffered a pronounced lower of their sensorial perceptions and quickly showed signs of poor adaptation to unknown environments and new situations.

From a physiological standpoint, the abnormal mice had very thick nerve cells and offered dysfunctions of myelin, the substance that surrounds the physique?s neurons, enabling the transmission of nervous impulses. These anatomical abnormalities characteristic to the mice with the PTEN gene deleted are an enormous step forward in understanding the occurrence of autism in humans. Nevertheless, now that medical scientists have been capable of simulate the symptoms of autism in mice, new medical remedies could be examined in an try to reverse the neurological harm brought on by the disorder.

The medical scientists who performed the experiment had been capable of reveal many similarities between the behaviors of mice with the PTEN gene deleted and the behaviors of individuals with autism. The abnormal mice involved within the experiment confirmed much more interest in various objects moderately than in different mice. Additionally they grew to become passive, and withdrawn, avoiding any type of interaction with different mice. They began to point out indicators of poor adaptability, failing to combine into new environments. Additionally, the mice with the deleted gene became careworn when confronted with new situations, unlike normal mice, which didn?t expertise difficulties in adapting to unknown scenarios. The key distinction, nevertheless, was that unlike autistic people, the abnormal mice did not present any indicators of repetitive behaviors or insistence on sameness.

The general results of the experiment reveal a robust connection between the PTEN gene and irregular behavioral patterns. Nonetheless, medical scientists aren?t yet in a position to tell if dysfunctions of this particular gene are additionally accountable for causing autism in humans.

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Source: http://articlelearn.net/is-autism-the-consequence-of-genetic-dysfunctions/

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